Police activity connected to the search for Nancy Guthrie, the missing mother of US news anchor Savannah Guthrie, is under way at a residence about two miles from her home.

Armed police teams have been seen coming in and going from the area, with a sheriff's vehicle blocking the road.

It comes after local officials said investigators had found DNA at Guthrie's address which does not belong to her or anyone close to her.

The 84-year-old disappeared in the middle of night from her home in Tucson, Arizona, nearly two weeks ago. Authorities believe she was taken against her will.

In a social media post, the sheriff's department said law enforcement activity was ongoing related to the Guthrie case without providing further details.

Pima County Sheriff Chris Nanos told local media outlet KOLD that investigators were actively working a lead as they search for clues related to her disappearance.

More than a dozen law enforcement vehicles, including SWAT teams and forensics, have been observed in the vicinity, with investigators collecting various pieces of evidence, including gloves found nearby.

The sheriff's department emphasized that reports of any gloves found inside her home are inaccurate. All collected evidence has been sent for laboratory analysis.

Authorities have released a description of a suspect, believed to be male and approximately 5'9 to 5'10 tall, captured on a doorbell camera outside Guthrie's home. An appeal for anyone with video footage from the neighborhood has also been made.

Nancy Guthrie requires daily medication and has limited mobility, intensifying concerns for her safety.

Her children, including Savannah, have taken to social media with pleas for her safe return, expressing their belief that she is still alive and their willingness to offer a reward for her safe return.