Bono, whose birth name is Paul David Hewson, is celebrated for his activism against poverty and initiatives related to HIV/Aids. Meanwhile, Wintour has played a pivotal role in the fashion industry as Vogue's editor-in-chief since 1988, raising over $20 million for AIDS research and rallying support for UK arts after funding cuts in 2022.

George Soros, a prominent financier and vocal critic of former President Donald Trump, joins former US Secretary of State Hillary Clinton, another recipient. Clinton is set to receive the honor shortly before her former political rival takes office.

The prestigious medal will also be awarded to a variety of other cultural and sports luminaries, including actors like Denzel Washington and Michael J. Fox, football superstar Lionel Messi, basketball legend Earvin "Magic" Johnson, and fashion icon Ralph Lauren. Additionally, humanitarian chef José Andrés, British conservationist Jane Goodall, and science educator Bill Nye will be recognized.

Posthumously honored recipients include former US Attorney General Robert F. Kennedy, ex-Defense Secretary Ash Carter, civil rights leader Fannie Lou Hamer, and former Michigan Governor George W. Romney.

The Presidential Medal of Freedom, established by President John F. Kennedy, is awarded at the president's discretion, following recommendations from an advisory panel. Previously honored individuals encompass Olympic champions like Simone Biles and industry innovators such as Steve Jobs.